Early detection and treatment of cholangiocarcinoma
Early detection and treatment of cholangiocarcinoma
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DOI：
10.1053/jlts.2000.18688
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发表时间：
2000-11-01
影响因子：
4.6
通讯作者：
Gores, GJ
中科院分区：
文献类型：
--
作者：
Gores, GJ
1. 在西方国家，确定的发生胆管癌的主要危险因素是原发性硬化性胆管炎（PSC）。2． PSC 胆管癌的诊断需要高度怀疑，因为内镜刷细胞学和/或活检以及影像学检查通常对恶性肿瘤呈阴性。正电子发射断层扫描是一种很有前途的诊断胆管癌的成像方式，即使是 PSC.3 患者也是如此。血清碳水化合物抗原19-9值大于100 U/mL，对胆管癌的敏感性和特异性分别约为75%和80%。 4．对于某些早期胆管癌患者来说，肝移植是一种可行的治疗选择。通过使用术前放疗和化疗并通过剖腹探查术确保不存在转移，可以优化结果。
1. The major identified risk factor for the development of cholangiocarcinoma in Western countries is primary sclerosing cholangitis (PSC).2. The diagnosis of cholangiocarcinoma in PSC requires a high index of suspicion because endoscopic brush cytology and/or biopsies and imaging studies are often negative for malignancy. Positron emission tomography is a promising imaging modality for the diagnosis of cholangiocarcinoma, even in patients with PSC.3. A serum carbohydrate antigen 19-9 value greater than 100 U/mL has a sensitivity and specificity for cholangiocarcinoma of approximately 75% and 80%, respectively.4. Liver transplantation is a viable therapeutic option for Selected patients with early-stage cholangiocarcinoma. Outcomes are optimized by using preoperative radiation and chemotherapy and ensuring the absence of metastases by an exploratory laparotomy.