Too Late Prenatal Diagnosis of Fetal Toxoplasmosis: A Case Report
Too Late Prenatal Diagnosis of Fetal Toxoplasmosis: A Case Report
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DOI：
10.1159/000083903
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发表时间：
2005-04
影响因子：
2.2
通讯作者：
D. Nowakowska;M. Respondek-Liberska;E. Gołąb;B. Stray-Pedersen;K. Szaflik;T. Dzbeński;J. Wilczyński
中科院分区：
文献类型：
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作者：
D. Nowakowska;M. Respondek-Liberska;E. Gołąb;B. Stray-Pedersen;K. Szaflik;T. Dzbeński;J. Wilczyński
目的：我们描述了一例严重的胎儿脑积水由于弓形虫病，无法诊断，直到孕晚期由于缺乏血清学监测计划在怀孕期间，此外，这种情况下，分子生物学工具的诊断过程中的有用性。孕中期超声检查发现异常，孕28周时PCR和小鼠接种试验均证实羊水中存在弓形虫。给予范西达和亚叶酸。新生儿患有进行性脑积水，癫痫发作和病理性肌肉紧张;超声检查显示大量脑钙化。眼科检查发现双侧脉络膜视网膜炎。抗T抗体检测证实为先天性弓形虫病.新生儿血清弓形虫IgM和伊加。结论：本病例是一例在子宫内诊断和治疗的严重胎儿弓形虫病。
Objective: We describe a case of severe fetal hydrocephalus due to toxoplasmosis which could not be diagnosed until late gestational age due to the lack of a serologic surveillance program during pregnancy; moreover, this case points to the usefulness of molecular biology tools in the diagnostic process. Abnormal ultrasound in the 2ndtrimester was noticed and Toxoplasma gondii was demonstrated in amniotic fluid at the 28th week of gestation both by PCR and by mice inoculation. Fansidar and folinic acid were administered. The newborn suffered from progressive hydrocephalus, seizures, and pathological muscular tonus; ultrasound examination showed massive cerebral calcifications. Ophthalmologic examination revealed bilateral choroidoretinitis. Congenital toxoplasmosis was confirmed by the detection of anti- T. gondii IgM and IgA in the neonatal serum. Conclusion: The presented case is an example of severe fetal toxoplasmosis diagnosed and treated in utero.