THE INTERLEUKIN-2 T-CELL SYSTEM - A NEW CELL-GROWTH MODEL
THE INTERLEUKIN-2 T-CELL SYSTEM - A NEW CELL-GROWTH MODEL
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DOI：
10.1126/science.6427923
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
SMITH, KA
中科院分区：
文献类型：
--
作者：
CANTRELL, DA;SMITH, KA
同步白细胞介素-2受体阳性T细胞，均相免疫亲和纯化的白细胞介素-2，和白细胞介素-2受体的单克隆抗体被用来表明，只有三个因素是T细胞周期进展的关键：白细胞介素-2浓度，白细胞介素-2受体密度，和白细胞介素-2受体相互作用的持续时间。由于T细胞的增殖特性与原核细胞和所有其他真核细胞的增殖特性相同，这些发现提供了一个新的模型，完全解释了决定细胞周期进程的变量。
Synchronized interleukin-2 receptor-positive T cells, homogeneous immunoaffinity-purified interleukin-2, and a monoclonal antibody to interleukin-2 receptors were used to show that only three factors are critical for T-cell cycle progression: interleukin-2 concentration, interleukin-2 receptor density, and the duration of the interleukin-2 receptor interaction. Since the proliferative characteristics of T cells are identical to those of both prokaryotic and all other eukaryotic cells, these findings provide a new model that accounts fully for the variables that determine cell cycle progression.