Novel SARS-CoV-2/COVID-19: Origin, pathogenesis, genes and genetic variations, immune responses and phylogenetic analysis
Novel SARS-CoV-2/COVID-19: Origin, pathogenesis, genes and genetic variations, immune responses and phylogenetic analysis
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DOI：
10.1016/j.genrep.2020.100752
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发表时间：
2020-09-01
期刊：
影响因子：
1.3
通讯作者：
Khan, Musarrat Abbas
中科院分区：
文献类型：
--
作者：
Junejo, Yasmeen;Ozaslan, Mehmet;Khan, Musarrat Abbas
本文从新型冠状病毒（SARS-CoV-2）的起源、发病机制、免疫应答、基因和遗传变异、系统发育分析以及潜在的治疗策略等方面进行综述，旨在为开发广泛有效的预防和疫苗提供参考。到2019年底，SARS-CoV-2与SARS一起出现，后来被命名为COVID-19，在全球范围内造成混乱的环境，并感染了大量生命。截至2020年6月3日（https：//www.example.com），由于这些流行病或大流行病已蔓延至全球210个国家和地区以及2个国际组织，确诊病例达6，467，229例，其中死亡382，766例，因此世界卫生组织宣布其为全球突发公共卫生事件。www.worldometers.info/coronavirus/没有临床批准的疫苗或抗病毒药物可用于新的或旧的冠状病毒感染;因此，开发有效的治疗和预防策略，可以随时科普这些菌株。
In this review, we focused on the origins of the novel coronavirus (SARS-CoV-2), origin, pathogenesis, immune responses, genes and genetic variations, phylogenetic analyses, and potential therapeutic strategies to summarize approaches for developing broadly effective preventions and vaccines to cope COVID-19. Towards the end of 2019, SARS-CoV-2 has emerged in association with the SARS, later was named COVID-19 caused an environment of chaos worldwide and infected a massive number of lives. Since these epidemics or pandemics had spread to 210 countries and territories around the world and 2 international conveyances with 6,467,229 confirmed cases, including, 382,766 deaths, as of June 03, 2020 (https://www.worldometers.info/coronavirus/ ), hence the World Health Organization declared it as a global Public Health Emergency. There are no clinically approved vaccines or antiviral drugs available for either of new or old corona infections; thus, the development of effective therapeutic and preventive strategies that can be readily available to cope with these strains.