Adjuvant polyarthritis. VIII. Differences in immunopathogenesis between type II collagen arthritis and adjuvant arthritis.
Adjuvant polyarthritis. VIII. Differences in immunopathogenesis between type II collagen arthritis and adjuvant arthritis.
复制标题
佐剂性多关节炎。
DOI：
10.1007/bf01966768
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Iizuka,Y
中科院分区：
文献类型：
--
作者：
Chang,YH;Iizuka,Y
研究发现，II 型胶原诱导的关节炎的严重程度与抗 II 型胶原抗体的血清水平相关，但与细胞介导的针对 II 型胶原的免疫无关。相比之下，在患有弗氏完全佐剂诱发关节炎的ras中，没有发现针对II型胶原的体液免疫或细胞介导的免疫水平显着。用II型胶原油性制剂对幼年大鼠进行预处理，可预防这些动物随后注射II型胶原油性制剂后发生关节炎，但对随后注射弗氏完全佐剂后关节炎的发生没有影响。结论是，虽然针对注射的 II 型胶原的免疫反应是 II 型胶原关节炎的发生的原因，但它在弗氏佐剂诱导的关节炎的诱导中并不起重要作用。
The severity of type II collagen-induced arthritis was found to correlate with the serum tiers of anti-type II collagen antibody, but not with cell-mediated immunity to type II collagen. In contrast, no significant levels of either the humoral or the cell-mediated immunity to type II collagen were found in ras with Freund's complete adjuvant-induced arthritis. Pre-treatment of young rats with an oily preparation of type II collagen prevented the development of arthritis in these animals in response to a subsequent injection of oily preparation of type II collagen, but had no effect on the development of arthritis in response to a subsequent injection of Freund's complete adjuvant. It is concluded that while an immune response directed toward the injected type II collagen is responsible for the development of type II collagen arthritis, it does not play an important role in the induction of Freund's adjuvant-induced arthritis.