ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL
ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL
复制标题
DOI：
10.1073/pnas.0503017102
复制
发表时间：
2005-07-19
影响因子：
11.1
通讯作者：
Conaway, RC
中科院分区：
文献类型：
--
作者：
Kong, SE;Banks, CAS;Conaway, RC
在人类细胞中，ELL转录因子家族至少包括三个成员，它们都能够通过抑制RNA聚合酶II在DNA沿着许多位点的瞬时暂停来刺激RNA聚合酶II的总延伸速率。在这份报告中，我们确定了ELL相关因子（EAF）1和EAF 2作为ELL延伸活性的强阳性调节因子。我们的研究结果提供了ELL家族转录因子的结构和功能的见解，他们带来光的EAF蛋白在RNA聚合酶11转录调节的直接作用。
In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase 11 transcription.