ROLE OF THE TIME FACTOR IN SIGNALING SPECIFICITY - APPLICATION TO MITOGENIC AND METABOLIC SIGNALING BY THE INSULIN AND INSULIN-LIKE GROWTH-FACTOR-I RECEPTOR TYROSINE KINASES
ROLE OF THE TIME FACTOR IN SIGNALING SPECIFICITY - APPLICATION TO MITOGENIC AND METABOLIC SIGNALING BY THE INSULIN AND INSULIN-LIKE GROWTH-FACTOR-I RECEPTOR TYROSINE KINASES
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DOI：
10.1016/0026-0495(95)90214-7
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发表时间：
1995-10-01
影响因子：
9.8
通讯作者：
SHYMKO, RM
中科院分区：
文献类型：
--
作者：
DEMEYTS, P;CHRISTOFFERSEN, CT;SHYMKO, RM
由激素、生长因子和细胞因子激活的信号转导通路显示出非同寻常的串扰和冗余。这篇综述讨论了如何通过信号网络保持结合步骤所赋予的特异性，尽管多个信号在共同的传出通路上汇聚，例如丝裂原激活蛋白(MAP)激酶。通过配体诱导二聚体激活受体的机制提供了一个既有开关又有计时器的信号装置。讨论了时间因素(即信号动力学)作为选择性决定因素的作用，重点讨论了受体酪氨酸激酶和细胞因子受体，特别是胰岛素和胰岛素样生长因子-I(IGF-I)对有丝分裂和代谢信号的影响。版权所有(C)1995，由W.B.Saunders公司提供。
The signal transduction pathways activated by hormones, growth factors, and cytokines show an extraordinary degree of cross-talk and redundancy. This review addresses the question of how the specificity conferred at the binding step is maintained through the signaling network despite the convergence of multiple signals on common efferent pathways such as mitogen-activated protein (MAP) kinase. The mechanism of receptor activation by ligand induced dimerization provides a signaling device with both a switch and a timer. The role of the time factor, ie, of signaling kinetics, as a determinant of selectivity is discussed with emphasis on the receptor tyrosine kinases and cytokine receptors, and especially mitogenic versus metabolic signaling by insulin and insulin-like growth factor-I (IGF-I). Copyright (C) 1995 by W.B. Saunders Company.