Diagnostic properties of metabolic perturbations in rheumatoid arthritis.
Diagnostic properties of metabolic perturbations in rheumatoid arthritis.
复制标题
DOI：
10.1186/ar3243
复制
发表时间：
2011-02-08
影响因子：
4.9
通讯作者：
Trygg J
中科院分区：
文献类型：
--
作者：
Madsen RK;Lundstedt T;Gabrielsson J;Sennbro CJ;Alenius GM;Moritz T;Rantapää-Dahlqvist S;Trygg J
本研究的目的是评估通过测量选定的代谢生物标志物诊断早期类风湿关节炎（RA）的可行性。我们比较了RA患者与健康对照组和银屑病关节炎（PsoA）患者的代谢特征。使用两种不同的色谱-质谱平台测量代谢物，从而对血清代谢物进行了广泛的概述。使用多变量统计分析比较患者组和对照组的代谢谱。这些发现在RA患者和健康志愿者的随访研究中得到了验证。在一项使用52种代谢物检测的验证研究中，诊断RA患者的敏感性为93%，特异性为70%。鉴别RA和PsoA的敏感性为90%，特异性为94%。与健康对照组相比，RA患者的甘油酸、D-呋喃核糖和次黄嘌呤升高，而组氨酸、苏糖酸、蛋氨酸、胆固醇、天冬酰胺和苏氨酸均降低。代谢物分析（代谢组学）是一种潜在的有用的技术，用于诊断RA。预测值与抗环瓜氨酸肽抗体的存在无关。
The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls. Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides.
登录
查看更多内容
影响因子：
27.4
作者：
Forslind, K;Ahlmén, M;Svensson, B
通讯作者：
Svensson, B
影响因子：
7.4
作者：
Jiye, A;Trygg, J;Moritz, T
通讯作者：
Moritz, T
影响因子：
7.4
作者：
Jonsson, P;Johansson, AI;Moritz, T
通讯作者：
Moritz, T
影响因子：
6.2
作者：
Keun, HC;Ebbels, TMD;Nicholson, JK
通讯作者：
Nicholson, JK
影响因子：
7.4
作者：
Slupsky, Carolyn M.;Rankin, Kathryn N.;Marrie, Thomas J.
通讯作者：
Marrie, Thomas J.