Regulation of proto-oncogene expression during T lymphocyte activation and proliferation.
Regulation of proto-oncogene expression during T lymphocyte activation and proliferation.
复制标题
T 淋巴细胞活化和增殖过程中原癌基因表达的调节。
DOI：
10.1007/978-1-4684-5323-2_25
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发表时间：
1987
影响因子：
--
通讯作者：
Hoover,RG
中科院分区：
文献类型：
--
作者：
Reed,JC;Prystowsky,MB;Kern,JA;Alpers,JD;Nowell,PC;Hoover,RG
T淋巴细胞的增殖部分通过其抗原和T细胞生长因子（白细胞介素2，IL-2）的膜受体来调节。在存在辅助细胞的情况下，特异性抗原或促有丝分裂细胞（植物血凝素、伴刀豆球蛋白A）刺激静息T细胞，辅助细胞携带由主要组织相容性复合体（MHC）基因座中的基因编码的表面抗原，诱导T细胞表达IL-2受体，并（部分但不是全部T细胞）分泌这种生长因子。IL-2与抗原或凝集素激活的T细胞上的细胞受体的相互作用随后导致转铁蛋白受体的表达。在细胞周期的G1期晚期，血清转铁蛋白与其受体的结合是T细胞经历G1→ S期转变所必需的，从而启动DNA合成并最终导致细胞分裂。其他生长因子，包括胰岛素和胰岛素样生长因子，似乎并不必要，至少对于T细胞的短期生长来说是如此（在1-3中进行了综述）。
The proliferation of T lymphocytes is regulated in part through their membrane receptors for antigen and for T cell growth factor (interleukin 2, IL-2). Stimulation of resting T cells by specific antigen or by mitogenic cells (phytohemagglutinin, concanavalin A) in the presence of accessory cells bearing surface antigens encoded by genes in the major histocompatibility complex (MHC) locus induces T cells to express receptors for IL-2 and (some but not all T cells) to secrete this growth factor. The interaction of IL-2 with its cellular receptor on antigen- or lectin-activated T cells subsequently results in expression of transferrin receptors. Binding of serum transferrin to its receptor in late G1phase of the cell cycle is then required for T cells to undergo the G1→ S phase transition, thereby initiating DNA synthesis and resulting ultimately in cell division. Other growth factors, including insulin and insulin-like growth factors, do not appear necessary, at least for short-term growth of T cells (reviewed in 1–3).