Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening.
Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening.
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DOI：
10.1038/s41598-021-83007-4
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发表时间：
2021-02-23
影响因子：
4.6
通讯作者：
Shimizu M
中科院分区：
文献类型：
--
作者：
Ibuka T;Adachi S;Horibe Y;Ohno T;Mabuchi M;Suzuki Y;Yamauchi O;Takada E;Iwama M;Saito K;Arao M;Takai K;Araki H;Shimizu M
粪便免疫化学试验（FIT）是一种广泛应用于结直肠癌筛查的工具。抗栓药物可能影响FIT对结直肠肿瘤的筛查效果。本研究的目的是阐明抗血栓药物在筛查结直肠肿瘤时对FIT准确性的影响。这项回顾性研究共纳入了758名同时接受FIT和全结肠镜检查的患者。探讨抗栓药物对FIT检测结直肠癌（CRC）、晚期腺瘤（AA）、非晚期腺瘤（NAA）等结直肠肿瘤（CN）准确性的影响。758例患者中144例（19%）接受抗栓药物治疗（给药组）。给药组有61/144例（42%）CN [CRC:14, AA:15, NAA:32]，非给药组有217/614例（35%）CN （CRC:43, AA:56, NAA:118）。两组间CN患病率差异无统计学意义（p = 0.1157）。使用抗栓药物或不使用抗栓药物检测各类型CN的敏感性和特异性无显著差异。抗栓药物对FIT阳性预测值和阴性预测值均无影响。服用抗栓药物可能对FIT筛查CN的敏感性、特异性、阳性预测值或阴性预测值没有太大影响。
Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p = 0.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN.
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影响因子：
29.4
作者：
Grobbee, Esmee J.;Schreuders, Eline H.;Kuipers, Ernst J.
通讯作者：
Kuipers, Ernst J.
影响因子：
9.8
作者：
Levi, Zohar;Rozen, Paul;Niv, Yaron
通讯作者：
Niv, Yaron
DOI：
10.1056/nejmoa1100370
发表时间：
2012-02-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Zauber AG;Winawer SJ;O'Brien MJ;Lansdorp-Vogelaar I;van Ballegooijen M;Hankey BF;Shi W;Bond JH;Schapiro M;Panish JF;Stewart ET;Waye JD
通讯作者：
Waye JD
影响因子：
8.8
作者：
Nakajima, M;Saito, H;Munakata, A
通讯作者：
Munakata, A
影响因子：
120.7
作者：
Brenner, Hermann;Tao, Sha;Haug, Ulrike
通讯作者：
Haug, Ulrike