Innate and Adaptive Interleukin-17-producing Lymphocytes in Chronic Inflammatory Lung Disorders
Innate and Adaptive Interleukin-17-producing Lymphocytes in Chronic Inflammatory Lung Disorders
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DOI：
10.1164/rccm.201007-1196pp
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发表时间：
2011-04-15
影响因子：
24.7
通讯作者：
Meyts, Isabelle
中科院分区：
文献类型：
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作者：
Vanaudenaerde, Bart M.;Verleden, Stijn E.;Meyts, Isabelle
在特定的细胞因子环境中，在T细胞受体激活过程中，幼稚的CD41(+) T细胞可以分化成由细胞因子产生模式和转录因子定义的谱系：T辅助型1（Th1）、Th2、Th17和Th22细胞；滤泡辅助性T细胞；和诱导调节性T细胞。Th17细胞已被认为是Th细胞的一个独特谱系，并且IL-17与人类疾病之间的关联已经被认识得更长一些。将IL-17限制在Th17细胞是一种过度简化。事实上，IL-17也在其他细胞中表达，包括产生IL-17的γ δ T （γ δ T-17）细胞、自然杀伤T-17细胞和产生IL-17的淋巴组织诱导细胞。IL-17于1995年被克隆为一种由T细胞表达的细胞因子，对上皮细胞、内皮细胞和成纤维细胞发挥炎症作用。IL-17是先天免疫和适应性免疫之间的坚实联系，可以发挥有益和有害的作用。IL-17 T细胞的发现为宿主防御、免疫调节和自身免疫提供了令人兴奋的新见解。毫无疑问，来自小鼠模型的数据对我们了解免疫机制做出了巨大贡献。然而，由于小鼠和人类免疫学之间存在许多差异，在小鼠中获得的数据并不能简单地互换。我们回顾了IL-17 T细胞在人类的情况下，更具体地说，它们在呼吸系统疾病中的潜在作用。我们对IL-17调控的理解的进步为解剖人类IL-17系统和反思肺部疾病的临床表现提供了机会。更重要的是，IL-17系统允许我们推测新的治疗机会。一些结果以前在摘要中报道过。
During T-cell receptor activation in a particular cytokine environment, naive CD41(+) T cells may differentiate into lineages defined by their pattern of cytokine production and transcription factors: T helper type 1 (Th1), Th2, Th17, and Th22 cells; follicular helper T cells; and inducible regulatory T cells. Th17 cells have been recognized as a distinct lineage of Th cells, and associations between IL-17 and human disease have been known somewhat longer. It would be an oversimplification to restrict IL-17 to Th17 cells. Indeed, IL-17 is also expressed by other cells including IL-17-producing gamma delta T (gamma delta T-17) cells, natural killer T-17 cells, and IL-17-producing lymphoid tissue-induced cells. IL-17 was cloned in 1995 as a cytokine expressed by T cells, exerting inflammatory effects on epithelial, endothelial, and fibroblast cells. IL-17 is a solid link between innate and adaptive immunity and can exert both beneficial and deleterious effects. The discovery of IL-17 T cells has provided exciting new insights into host defense, immunoregulation, and autoimmunity. Unquestionably, data from mouse models have contributed enormously to our insight into immunological mechanisms. However, because of numerous differences between murine and human immunology, data obtained in mice are not simply interchangeable. We review IL-17 T cells exclusively in the human situation and more specifically their potential role in respiratory diseases. The advances in our understanding of IL-17 regulation offer opportunities to dissect the human IL-17 system and to reflect on the clinical presentation of lung diseases. More importantly, the IL-17 system allows us to speculate on new therapeutic opportunities. Some results have been previously reported in an abstract.