A facile method for the rapid and selective deprotection of methoxymethyl (MOM) ethers
A facile method for the rapid and selective deprotection of methoxymethyl (MOM) ethers
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DOI：
10.1016/j.tet.2010.01.007
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发表时间：
2010-02-27
期刊：
影响因子：
2.1
通讯作者：
Ryu, Do Hyun
中科院分区：
文献类型：
--
作者：
Han, Jae Hyun;Kwon, Young Eun;Ryu, Do Hyun
We describe a rapid and efficient method for selective deprotection of methoxymethyl (MOM) ethers using ZnBt(2) and n-PrSH, which completely removed MOM from diverse MOM ethers of primary, secondary. and tertiary alcohols or phenol derivatives The deprotection takes less than ten minutes with both high yield and selectivity in the presence of other protecting groups In addition, the rapid deprotection of MOM ethers of tertiary hydroxyls in high yield with no epimerization allows MOM to be a suitable protecting group for tertiary alcohols (C) 2010 Elsevier Ltd All rights reserved
