The distribution of substance P, enkephalin, and serotonin immunoreactivities in the area postrema of the rat and cat.
The distribution of substance P, enkephalin, and serotonin immunoreactivities in the area postrema of the rat and cat.
复制标题
大鼠和猫后部区域 P 物质、脑啡肽和血清素免疫反应性的分布。
DOI：
10.1002/cne.902340107
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Traurig,H
中科院分区：
文献类型：
--
作者：
Newton,BW;Maley,B;Traurig,H
使用过氧化物酶-抗过氧化物酶技术的P物质（SP），脑啡肽（ENK），和5-羟色胺（5-HT）的免疫反应性的分布在大鼠和猫的最后区进行了描述。在这两个物种中，在最后区的免疫反应性的差异分布为纤维，或细胞体和纤维。在大鼠和猫中，ENK具有最大的免疫反应性纤维积聚，其次是5 HT和SP。在大鼠的最后区中，大多数SP-、ENK-和5 HT-免疫反应性纤维沿着腹侧和腹外侧边缘，在背侧表面具有较少的免疫染色纤维。猫的最后区在腹侧和外侧边缘具有大多数SP-、ENK-和5 HT-免疫反应性纤维，在背侧和内侧边缘具有较少的免疫染色纤维。在这两个物种中，最后区的中心区域含有最少的免疫染色纤维。在一般情况下，每个假定的神经递质检查，免疫染色纤维在这两个物种的数量逐渐减少rostrocaudally。在大鼠最后区发现5-羟色胺和ENK免疫反应性细胞体;在猫最后区仅存在ENK免疫反应性细胞体。两种动物的最后区均缺乏SP免疫反应阳性细胞体。大鼠和猫最后区内免疫反应纤维和胞体的不均匀分布可能反映了两种动物最后区的不同功能。
With the use of the peroxidase‐antiperoxidase technique the distribution of substance P (SP), enkephalin (ENK), and serotonin (5HT) immunoreactivities were described in the area postrema of the rat and cat. In both species, immunoreactivity in the area postrema was differentially distributed as either fibers only, or cell bodies and fibers. In the rat and cat, ENK had the greatest accumulation of immunoreactive fibers, followed by 5HT and SP. In the area postrema of the rat the majority of SP‐, ENK‐, and 5HT‐immunoreactive fibers were along the ventral and ventrolateral borders, with fewer immunostained fibers at the dorsal surface. The area postrema of the cat had the majority of SP‐, ENK‐, and 5HT‐immunoreactive fibers at the ventral and lateral borders, with fewer immunostained fibers at the dorsal and medial borders. In both species, the area postrema's central region contained the fewest immunostained fibers. In general, for each putative neurotransmitter examined, immunostained fibers in both species progressively decreased in number rostrocaudally. Serotonin‐ and ENK‐immunoreactive cell bodies were found in the rat area postrema; in the cat area postrema only ENK‐immunoreactive cell bodies were present. The area postrema of both species lacked SP‐immunoreactive cell bodies. The heterogeneous distribution of immunoreactive fibers and cell bodies within the area postrema of the rat and cat may reflect the different functions of the area postrema in both species.