Vascular endothelial growth factor in acute Kawasaki disease
Vascular endothelial growth factor in acute Kawasaki disease
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DOI：
10.1016/s0002-9149(98)00864-9
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发表时间：
1999-02-01
影响因子：
2.8
通讯作者：
Kohno, Y
中科院分区：
文献类型：
--
作者：
Terai, M;Yasukawa, K;Kohno, Y
Vascular endothelial growth factor (VEGF),also known as vascular permeability factor, is an important regulator of angiogenesis and blood vessel permeability. Kawasaki disease (KD) is characterized bysystemic vasculitis with increased vascular permeability, implying a possible role of VEGF in KD. To elucidate the involvement of VEGF in the pathogenesis of KD, we investigated 30 patients with acute KD, comparing the time course of plasma VEGF levels (n = 123) with clinical symptoms and laboratory findings. Compared with control values, the peak levels of plasma VEGF were significantly elevated (38 +/- 26 vs 244 +/- 248 pg/ml, p
