Anisotropy of Callosal Motor Fibers in Combination With Transcranial Magnetic Stimulation in the Course of Motor Development
Anisotropy of Callosal Motor Fibers in Combination With Transcranial Magnetic Stimulation in the Course of Motor Development
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DOI：
10.1097/rli.0b013e31819e9362
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发表时间：
2009-05-01
影响因子：
6.7
通讯作者：
Ertl-Wagner, Birgit
中科院分区：
文献类型：
--
作者：
Koerte, Inga;Heinen, Florian;Ertl-Wagner, Birgit
目的：胼胝体（CC）是手部运动发育的关键结构，可通过扩散张量磁共振成像（DTI）和经颅磁刺激（TMS）进行研究。为了确定可量化的标记为运动发育，我们结合DTI与TMS。材料和方法：我们检查组I 1健康学龄前儿童，10名健康青少年，和10名健康成人，DTI和TMS/同侧沉默期（iSP）。计算CC区域I至V的各向异性分数（FA）的DTI值。结果：儿童CC Ⅱ ~ Ⅳ区FA值明显低于成人（P < 0.05）。在胼胝体运动纤维穿过CC的III区，儿童和青少年的FA差异显著（P < 0.05）。经颅磁刺激各参数在iSP的持续时间和范围上有明显的年龄差异（P < 0.05）。没有显着差异检测到关于潜伏期的iSP.Conclusions：胼胝体运动纤维连接的成熟似乎反映了半球间的抑制程度与各向异性的胼胝体运动纤维之间的运动皮层是一个潜在的标记为电机的发展。
Objectives: The corpus callosum (CC) represents a key structure for hand motor development and is accessible to investigation by diffusion tensor magnetic resonance imaging (DTI) and transcranial magnetic stimulation (TMS). To identify quantifiable markers for motor development, we combined DTI with TMS.Materials and Methods: We examined groups of I 1 healthy preschool-aged children, 10 healthy adolescents, and 10 healthy adults with both, DTI and TMS/ipsilateral silent period (iSP). DTI-values for fractional anisotropy (FA) were calculated for areas I to V of the CC. ISP-values for latency, duration, and extent of electromyography suppression were calculated.Results: FA was significantly lower in areas II to IV of the CC in children as compared with adults (P < 0.05). In area III, where callosal motor fibers cross the CC, FA differed significantly between children and adolescents (P < 0.05). TMS parameters demonstrated significant age-related differences in duration and extent of iSP (P < 0.05). No significant differences were detected regarding latency of iSP.Conclusions: The maturation of callosal motor fiber connectivity seems to reflect the degree of interhemispheric inhibition between the motor cortices with anisotropy of callosal motor fibers being a potential marker for motor development.