Preventive chemotherapy as a strategy for elimination of neglected tropical parasitic diseases: endgame challenges.

Preventive chemotherapy as a strategy for elimination of neglected tropical parasitic diseases: endgame challenges.
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DOI:
10.1098/rstb.2012.0144
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发表时间:
2013-08-05
期刊:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子:
--
通讯作者:
Molyneux DH
Molyneux DH
中科院分区:
其他
文献类型:
--
作者:
Bockarie MJ;Kelly-Hope LA;Rebollo M;Molyneux DH

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2012年1月的伦敦宣言刺激了全球应对被忽视的热带病的努力,包括比尔及梅林达·盖茨基金会、世界银行、世界卫生组织(卫生组织)和主要制药公司承诺维持和扩大NTD计划,到2020年消除或根除11种NTD,以实现最近公布的世卫组织路线图。在这里,我们提出了目前的情况下,一些NTD的预防性化疗,并讨论所面临的问题,因为他们认为的“残局”,如在冲突后的环境中,有限的人力和财力资源,并需要扩大获得清洁水和改善卫生条件的血吸虫病和土壤传播的蠕虫病的人口的困难。在盘尾丝虫病和淋巴丝虫病的情况下,伊维菌素治疗具有很大的风险,因为在一些同时感染热带眼虫Loa loa丝虫病的患者中会产生严重的不良反应。我们讨论管理复杂伙伴关系的挑战,并保持宣传信息,以继续支持消除这些可预防的疾病。
Global efforts to address neglected tropical diseases (NTDs) were stimulated in January 2012 by the London declaration at which 22 partners, including the Bill & Melinda Gates Foundation, World Bank, World Health Organization (WHO) and major pharmaceutical companies committed to sustaining and expanding NTD programmes to eliminate or eradicate 11 NTDs by 2020 to achieve the goals outlined in the recently published WHO road map. Here, we present the current context of preventive chemotherapy for some NTDs, and discuss the problems faced by programmes as they consider the ‘endgame’, such as difficulties of access to populations in post-conflict settings, limited human and financial resources, and the need to expand access to clean water and improved sanitation for schistosomiasis and soil-transmitted helminthiasis. In the case of onchocerciasis and lymphatic filariasis, ivermectin treatment carries a significant risk owing to serious adverse effects in some patients co-infected with the tropical eye worm Loa loa filariasis. We discuss the challenges of managing complex partnerships, and maintain advocacy messages for the continued support for elimination of these preventable diseases.
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