Prognostic Significance of Pre-Operative Monocyte-to-Lymphocyte Ratio in Lung Cancer Patients Undergoing Radical Surgery
Prognostic Significance of Pre-Operative Monocyte-to-Lymphocyte Ratio in Lung Cancer Patients Undergoing Radical Surgery
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DOI：
10.1093/labmed/lmx069
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发表时间：
2018-05-01
影响因子：
1.3
通讯作者：
Chen, Yu
中科院分区：
文献类型：
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作者：
Chen, Xiaoling;Wu, Jinbiao;Chen, Yu
背景：炎症反应在肿瘤的发生和发展中起着重要作用。单核细胞与淋巴细胞比率（MLR）作为炎症反应的生物标志物，其预后相关性已在血液系统癌症患者中得到证实。目的：在这项研究中，我们评估了MLR在可切除肺癌患者中的预后相关性。对2006年10月至2011年1月期间在我院行根治性切除术的705例肺癌患者的临床记录进行了分析。回顾性审查。根据受试者工作特征曲线分析确定MLR作为预后指标的最佳截止值。多因素分析采用考克斯比例风险回归模型，MLR是一个独立的预测总生存期和（风险比[HR] 1.494，95%置信区间[CI] 1.158-1.927，P = .002）和无病生存期结论：术前MLR可作为肺癌患者危险分层的一个简单、可靠的预后指标，并可用于指导治疗决策。
Background: Inflammatory response is known to play a vital role in carcinogenesis and cancer progression. The prognostic relevance of monocyte-to-lymphocyte ratio (MLR), as a biomarker of inflammatory response has been demonstrated in patients with hematologic cancers.Objectives: In this study, we assessed the prognostic relevance of MLR in patients with resectable lung carcinoma.Methods: Clinical records of 705 lung cancer patients who underwent radical resection at our hospital between October 2006 and January 2011 were retrospectively reviewed. The optimal cutoff value of MLR as a prognostic indicator was determined on receiver operating characteristic curve analysis.Results: On multivariate analysis using Cox proportional hazards regression model, MLR was an independent predictor of both overall survival (hazard ratio [HR] 1.494, 95% confidence interval [CI] 1.158-1.927, P = .002) and disease-free survival (HR 1.547, 95% CI 1.172-2.043, P = .002).Conclusions: Preoperative MLR may be a simple, reliable prognostic marker for risk stratification and be used to guide treatment decision-making in lung cancer patients.