Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients.
Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients.
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基因表达谱鉴定女性糖尿病周围神经病变患者神经营养蛋白-MAPK 信号通路的下调。
DOI：
10.1155/2017/8103904
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发表时间：
2017
影响因子：
4.3
通讯作者：
Ji LD
中科院分区：
文献类型：
--
作者：
Luo L;Zhou WH;Cai JJ;Feng M;Zhou M;Hu SP;Xu J;Ji LD
糖尿病周围神经病变（DPN）是糖尿病（DM）的常见并发症。由于其发病机制仍有争议，大多数患者未得到正确诊断或治疗。在这项研究中，人类全基因组微阵列确定了2898和4493差异表达的基因（DEG）在糖尿病和糖尿病周围神经病变患者分别。进一步的KEGG通路分析表明DPN和DM共有4条通路，包括细胞凋亡、B细胞受体信号通路、内吞作用和Toll样受体信号通路。DPN和DM的DEG中MAPK信号通路、NOD样受体信号通路和神经营养因子信号通路明显富集，而“神经营养因子-MAPK信号通路”明显下调。在另外78个样本中验证了来自神经营养素-MAPK信号通路的7个DEG，结果证实了最初的微阵列发现。这些结果表明，下调神经营养素-MAPK信号通路可能是DPN发病的主要机制，从而为DPN的治疗提供了一个潜在的途径。
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial. In this study, human whole genome microarrays identified 2898 and 4493 differentially expressed genes (DEGs) in DM and DPN patients, respectively. A further KEGG pathway analysis indicated that DPN and DM share four pathways, including apoptosis, B cell receptor signaling pathway, endocytosis, and Toll-like receptor signaling pathway. The DEGs identified through comparison of DPN and DM were significantly enriched in MAPK signaling pathway, NOD-like receptor signaling pathway, and neurotrophin signaling pathway, while the “neurotrophin-MAPK signaling pathway” was notably downregulated. Seven DEGs from the neurotrophin-MAPK signaling pathway were validated in additional 78 samples, and the results confirmed the initial microarray findings. These findings demonstrated that downregulation of the neurotrophin-MAPK signaling pathway may be the major mechanism of DPN pathogenesis, thus providing a potential approach for DPN treatment.
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影响因子：
5.8
作者：
Doupis, John;Lyons, Thomas E.;Veves, Aristidis
通讯作者：
Veves, Aristidis
影响因子：
2.3
作者：
Haug, A. T.;Braun, K. F.;Freude, T.
通讯作者：
Freude, T.
影响因子：
5.3
作者：
HELLWEG, R;RAIVICH, G;KREUTZBERG, GW
通讯作者：
KREUTZBERG, GW
影响因子：
158.5
作者：
Duckworth, William;Abraira, Carlos;Huang, Grant D.
通讯作者：
Huang, Grant D.
影响因子：
7.6
作者：
Andriankaja, O. M.;Galicia, J.;Graves, D. T.
通讯作者：
Graves, D. T.