Sex differences and role of nitric oxide in blood flow of canine urinary bladder.
Sex differences and role of nitric oxide in blood flow of canine urinary bladder.
复制标题
性别差异及一氧化氮在犬膀胱血流中的作用。
DOI：
10.1152/ajpregu.1999.276.2.r407
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Ruggieri,MR
中科院分区：
文献类型：
--
作者：
Pontari,MA;Ruggieri,MR
用激光多普勒血流仪连续测量麻醉犬膀胱充盈和排空过程中的膀胱血流量。在粘膜和肌肉中，灌注与膀胱内压成反比。在基线和高达10 cm水充盈压时，雄性膀胱粘膜的灌注显著高于雌性，但肌肉中的灌注不显著。动脉内输注一氧化氮合酶激动剂NG-硝基-L-精氨酸仅在粘膜中产生静息膀胱灌注的显著减少，对膀胱内压的反应没有差异。动脉内输注的l-精氨酸产生了显着增加的灌注水平，在粘膜中看到后，立即膀胱引流。左旋精氨酸治疗后，肌肉灌注无明显变化。这些结果表明膀胱粘膜的灌注因性别而异，并且与膀胱肌肉不同地调节，可能与两层的不同功能有关。
Continuous measurements were made of bladder blood flow by laser Doppler flowmetry in anesthetized dogs during bladder filling and emptying. In both mucosa and muscle, perfusion was inversely proportional to intravesical pressure. There was significantly greater perfusion in the bladder mucosa of males than females at baseline and up to 10 cm water filling pressure but not in the muscle. Intra-arterial infusion of the nitric oxide synthase inhibitorNG-nitro-l-arginine produced a significant decrease in resting bladder perfusion in the mucosa only, with no differences seen in the response to intravesical pressure. Intra-arterial infusion ofl-arginine produced a significant increase in the level of perfusion in the mucosa seen immediately after the bladder was drained. No changes were observed in muscle perfusion afterl-arginine. These results suggest that the perfusion of the bladder mucosa differs by gender and is regulated differently than the bladder muscle, possibly related to the different function of the two layers.