Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources.
Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources.
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证明细胞内和血管内来源的 FFA 氧化之间的新型反馈机制。
DOI：
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发表时间：
1991
影响因子：
--
通讯作者：
M. Taskinen
中科院分区：
文献类型：
--
作者：
Hannele Yki;I. Puhakainen;C. Saloranta;L. Groop;M. Taskinen
我们研究了体内细胞内和血管内脂解的调节。在第一系列研究中，非胰岛素依赖型糖尿病（NIDDM）患者和正常受试者的血浆游离脂肪酸（FFA）通过肝素（加约600 μ mol/l）中度升高。血浆FFA的增加以血浆FFA浓度依赖性方式“次最大程度”增加血浆FFA氧化（血浆FFA氧化低于总脂质氧化的100%）。血浆FFA氧化的增加显著抑制FFA的直接细胞内氧化。在另一组NIDDM患者中，血浆FFA显着增加（增加约1，500 mumol/l）。血浆FFA氧化现在占所有脂质氧化。与在相似胰岛素浓度下，在相同受试者血浆游离脂肪酸亚最大限度升高时观察到的底物氧化速率相比，总脂质氧化增加，碳水化合物氧化减少，总能量产生增加。这些数据表明，存在FFA依赖性胰岛素非依赖性反馈机制之间的FFA氧化从细胞内和血管内来源。因此，身体组织对血浆FFA氧化变化的优选反应是直接细胞内FFA氧化的相互变化。如P. J. Randle等人（Lancet 1：785，1963）所提出的，在利用了脂质氧化组分内的调节能力之后，碳水化合物和脂质之间的底物竞争开始起作用。
We examined the regulation of intracellular and intravascular lipolysis in vivo. In the first series of studies, plasma free fatty acids (FFA) were elevated moderately by heparin (plus approximately 600 mumol/l) in patients with non-insulin-dependent diabetes mellitus (NIDDM) and in normal subjects. The increase in plasma FFA increased plasma FFA oxidation "submaximally" (plasma FFA oxidation less than 100% of total lipid oxidation) in a plasma FFA concentration-dependent manner. The increase in plasma FFA oxidation significantly suppressed direct intracellular oxidation of FFA. In another group of patients with NIDDM, plasma FFA was markedly increased (plus approximately 1,500 mumol/l). Plasma FFA oxidation now accounted for all lipid oxidation. Compared with substrate oxidation rates observed at submaximally elevated plasma FFAs in the same subjects at similar insulin concentrations, total lipid oxidation increased, carbohydrate oxidation decreased, and total energy production increased. These data demonstrate the existence of an FFA-dependent insulin-independent feedback mechanism between FFA oxidation from intracellular and intravascular sources. Thus the preferred response of body tissues to a change in plasma FFA oxidation is a reciprocal change in direct intracellular FFA oxidation. Substrate competition between carbohydrate and lipid, as proposed by P. J. Randle et al. (Lancet 1:785, 1963), becomes operative after the capacity for regulation within components of lipid oxidation has been utilized.
影响因子：
15.9
作者：
FERRANNINI, E;BARRETT, EJ;DEFRONZO, RA
通讯作者：
DEFRONZO, RA
游离脂肪酸升高对正常人葡萄糖氧化的影响。
DOI：
10.1016/0026-0495(88)90131-x
发表时间：
1988
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Wolfe,BM;Klein,S;Peters,EJ;Schmidt,BF;Wolfe,RR
通讯作者：
Wolfe,RR
影响因子：
20.3
作者：
BERGMAN, RN;FINEGOOD, DT;ADER, M
通讯作者：
ADER, M