Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.
Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.
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DOI：
10.1039/c4bm00452c
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发表时间：
2015-07
影响因子：
6.6
通讯作者：
Cheng J
中科院分区：
文献类型：
--
作者：
Cai K;Yen J;Yin Q;Liu Y;Song Z;Lezmi S;Zhang Y;Yang X;Helferich WG;Cheng J
我们报告的设计和开发的氧化还原反应链破碎聚合物治疗剂（CSPTs）。采用缩聚法合成了CSPTs，并通过“Click”反应用聚乙二醇（PEG）对CSPTs进行了修饰。通过纳米沉淀形成具有高载药量（高达18%）的尺寸受控的CSPT纳米颗粒（NPs）;颗粒尺寸以浓度依赖性方式增加。在氧化还原触发后，药物从颗粒中的释放在48小时内得到很好的控制。在体外和体内验证了CSPT NP的抗癌功效。
We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via “Click” reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.