Zebrafish models in cardiac development and congenital heart birth defects.
Zebrafish models in cardiac development and congenital heart birth defects.
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DOI：
10.1016/j.diff.2012.05.005
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发表时间：
2012-07
期刊：
影响因子：
2.9
通讯作者：
Chi, Neil C.
中科院分区：
文献类型：
--
作者：
Tu, Shu;Chi, Neil C.
斑马鱼由于其遗传易感、体外受精、早期光学清晰度和在发育过程中没有心血管系统的生存能力而成为研究心脏发育的理想脊椎动物系统。特别是，成像技术的最新进展和斑马鱼转基因的创造现在允许对心脏形态发生过程中发生的动态细胞事件进行体内分析。因此，这些显著特征的结合提供了关于特定基因如何在细胞水平上影响心脏发育的详细见解。在这篇综述中，我们将重点介绍如何利用斑马鱼来阐明心脏发育和人类先天性心脏病（CHDs）的潜在机制，以及可能调节心脏再生的潜在途径。因此，我们根据冠心病的主要类别——结构性心脏、功能性心脏和血管/大血管缺陷——组织了这篇综述，并将总结如何进一步利用斑马鱼来帮助我们了解未来特定的人类冠心病。
The zebrafish has become an ideal vertebrate animal system for investigating cardiac development due to its genetic tractability, external fertilization, early optical clarity and ability to survive without a functional cardiovascular system during development. In particular, recent advances in imaging techniques and the creation of zebrafish transgenics now permit the in vivo analysis of the dynamic cellular events that transpire during cardiac morphogenesis. As a result, the combination of these salient features provides detailed insight as to how specific genes may influence cardiac development at the cellular level. In this review, we will highlight how the zebrafish has been utilized to elucidate not only the underlying mechanisms of cardiac development and human congenital heart diseases (CHDs), but also potential pathways that may modulate cardiac regeneration. Thus, we have organized this review based on the major categories of CHDs – structural heart, functional heart, and vascular/great vessel defects, and will conclude with how the zebrafish may be further used to contribute to our understanding of specific human CHDs in the future.
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