Effect of centrally and peripherally administered beta-endorphin on food intake in rats.
Effect of centrally and peripherally administered beta-endorphin on food intake in rats.
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中枢和外周给药β-内啡肽对大鼠食物摄入的影响。
DOI：
10.1111/j.1399-3011.1989.tb00702.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Li,CH
中科院分区：
文献类型：
--
作者：
Triscari,J;Nelson,D;Vincent,GP;Li,CH
β - EP在调节食物摄入中的作用已被认为是一些遗传性肥胖动物模型肥胖的一个促成因素。本文描述了为确定持续给药β - EP是否能改变正常大鼠的食物摄入量而进行的研究。目前的研究表明，持续皮下输注β - EP对调节食物摄入无效，但急性腹腔或脑室内给药分别刺激了先前食物剥夺或饱食的动物的食物摄入。这些结果表明β - EP不参与食物摄入的长期调节，但在一定条件下，它可能在单餐调节中发挥一定作用。据推测，后一种活性可能是其他食欲调节激素作用的结果。
A role for β‐EP in the regulation of food intake has been suggested as a contributory factor in the obesity of some genetically obese animal models. Studies undertaken to determine whether continuous administration of β‐EP could alter food intake in normal rats are described. The present studies demonstrated that continuous subcutaneous infusion with β‐EP was ineffective in modulating food intake, but that acute intraperitoneal or intracerebroventricular administration stimulated food intake in previously food deprived or satiated animals, respectively. These results suggest that β‐EP is not involved in the long‐term regulation of food intake, but under certain conditions it may play some role in the regulation of individual meals. It is speculated that the latter activity may result from the action of other appetitive regulatory hormones.