DIURNAL VARIATION OF PLASMA LEVELS AND URINARY EXCRETION OF 17-HYDROXY-CORTICOSTEROIDS IN NORMAL SUBJECTS, NIGHT WORKERS AND BLIND SUBJECTS
DIURNAL VARIATION OF PLASMA LEVELS AND URINARY EXCRETION OF 17-HYDROXY-CORTICOSTEROIDS IN NORMAL SUBJECTS, NIGHT WORKERS AND BLIND SUBJECTS
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DOI：
10.1210/jcem-16-5-622
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发表时间：
1956-01-01
影响因子：
5.8
通讯作者：
SAMUELS, LT
中科院分区：
文献类型：
--
作者：
MIGEON, CJ;TYLER, FH;SAMUELS, LT
正常人血浆17-羟皮质类固醇水平呈昼夜节律。在睡眠后期（早上5-8点）经常看到最大值，从上午8点到午夜，水平呈下降趋势，在高峰后的头几个小时下降得更快。在凌晨2点到6点之间，浓度迅速上升。尿中17-羟皮质类固醇的排泄遵循与血浆相同的一般变化曲线，但延迟约2小时。夜间工作者和盲人的昼夜变化与正常人相同。在正常人和夜班工人血浆铁浓度表现出周期性的17-羟皮质类固醇，但周期是不那么明确的盲人。嗜酸性粒细胞的浓度似乎存在一个逆循环，但个体差异是如此之大，以至于有相当程度的统计不确定性的变化的意义。
A diurnal rhythm in the levels of plasma 17-hydroxycorticosteroids of normal subjects was shown. A maximum value was regularly seen during the later hours of sleep (5-8 A.M.), usually near 6 A.M. From 8 A.M. to midnight the levels followed a downward trend, the decrease being more rapid in the first few hours after the peak. Between 2 A.M. and 6 A.M. the concentrations rose rapidly. 17-Hydroxycorti-costeroid excretion in urine followed the same general curve of variation as that of plasma, but was delayed about 2 hours. Night workers and blind had the same diural variation as the normal subjects. In normal subjects and in the night workers plasma iron concentrations manifested a periodicity like that of 17-hydroxycorticosteroids, but the cycle was not so definite in the blind individuals. An inverse cycle seemed to exist in concentrations of eosinophils, but individual variation was so great that there is a considerable degree of statistical uncertainty as to the significance of the variations.