In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa
In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa
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DOI：
10.1364/oe.1.000432
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发表时间：
1997-12-22
期刊：
影响因子：
3.8
通讯作者：
Streltzova, O. S.
中科院分区：
文献类型：
--
作者：
Sergeev, A. M.;Gelikonov, V. M.;Streltzova, O. S.
第一个结果的内窥镜应用光学相干断层扫描的人体粘膜在呼吸道，胃肠道，泌尿道和生殖道的体内研究。一种新型的内窥镜OCT（EOCT）系统已被创建，该系统基于将全光纤干涉仪的采样臂集成到标准内窥镜设备中，使用其活检通道将低相干辐射传输到所研究的组织。我们已经研究了食管、喉、胃、膀胱、宫颈和身体的粘膜作为癌过程的典型定位。记录并分析肿瘤组织与健康组织的图像。EOCT可以清楚地观察到癌变组织中分层良好的健康粘膜结构的破坏，从而使该技术有望用于肿瘤的早期诊断和切除活检的精确指导。(C)1997年美国光学学会
First results of endoscopic applications of optical coherence tomography for in vivo studies of human mucosa in respiratory, gastrointestinal, urinary and genital tracts are presented. A novel endoscopic OCT (EOCT) system has been created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, larynx, stomach, urinary bladder, uterine cervix and body as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancered tissue are distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy. (C) 1997 Optical Society of America