Remodeling of the piriform cortex after lesion in adult rodents.
Remodeling of the piriform cortex after lesion in adult rodents.
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DOI：
10.1097/wnr.0000000000000203
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发表时间：
2014-09-10
期刊：
影响因子：
1.7
通讯作者：
Koliatsos VE
中科院分区：
文献类型：
--
作者：
Rossi SL;Mahairaki V;Zhou L;Song Y;Koliatsos VE
Denervation of the piriform cortex by bulbotomy causes a series of important cellular changes in the inhibitory interneurons of layer I and transsynaptic apoptosis of a large number of pyramidal neurons in outer layer II within 24 h. In this study, we report that following the marked loss of neurons in outer layer II, the piriform cortex is reconstituted by the addition of newly formed neurons that restore the number to a preinjury level within 30 days. We provide evidence that the number of newly divided neuronal progenitors increases after injury and further show that a population of doublecortin-positive cells that resides in the piriform cortex decreases after injury. Taken together, these findings suggest that the piriform cortex has significant neurogenic potential that is activated following sensory denervation and may contribute toward the replacement of neurons in outer layer II.
