Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice
Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice
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DOI：
10.1111/ggi.12436
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发表时间：
2016-01
影响因子：
3.3
通讯作者：
R. Takahashi;S. Totsuka;A. Ishigami;Yoshiro Kobayashi;K. Nagata
中科院分区：
文献类型：
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作者：
R. Takahashi;S. Totsuka;A. Ishigami;Yoshiro Kobayashi;K. Nagata
体内产生的继发性坏死细胞诱导炎症反应；例如，巨噬细胞炎症蛋白- 2 （MIP - 2）的产生和随后中性粒细胞的浸润。本研究的目的是阐明衰老对继发性坏死细胞吞噬和炎症反应的影响，通过使用野生型（WT）年轻小鼠，WT老年小鼠或衰老加速小鼠（SMP30−/−小鼠）。
Secondary necrotic cells generated in vivo induce inflammatory responses; for example, the production of macrophage inflammatory protein‐2 (MIP‐2) and subsequent infiltration of neutrophils. The aim of the present study was to elucidate the effect of aging on the phagocytosis of secondary necrotic cells and the inflammatory responses by using either wild‐type (WT) young mice, WT aged mice or senescence‐accelerated mice (SMP30−/− mice).