Evaluating the current state of the art of Huntington disease research: a scientometric analysis.
Evaluating the current state of the art of Huntington disease research: a scientometric analysis.
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DOI：
10.1590/1414-431x20176299
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发表时间：
2018-01-11
期刊：
影响因子：
--
通讯作者：
Ghisi NC
中科院分区：
文献类型：
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作者：
Barboza LA;Ghisi NC
亨廷顿病（HD）是一种无法治愈的神经退行性疾病，由4号染色体上的显性突变引起。我们的目标是对现有的科学事业进行科学计量分析，以更好地了解HD。因此，进行了一项定量研究，以检查当前最先进的方法，以促进研究人员对当前知识、研究趋势和研究差距的理解。我们对截至2016年9月发表在“ISI Web of Science™”（http://apps.webofknowledge.com/）上的文章进行了文献检索。关键词是“亨廷顿病”。在最初获得的14,036篇文章中，根据其相关性，7732篇符合纳入研究的条件。数据按语言、出版国家、年份和集中地区分类。关于HD的研究发表数量最多的国家是美国，占所有发表量的近30%，其次是英国和德国，分别占所有发表量的10%和7%。就撰写文章的语言而言，98%的出版物是英文的。第一本在HD上找到的出版物是在1974年出版的。从1996年开始，HD版本的出版物数量激增。与出现的各种知识领域相关，大多数出版物都在神经科学和神经学领域，可能是因为HD是一种神经退行性疾病。在精神病学、遗传学和分子生物学等领域的出版物也占主导地位。
Huntington disease (HD) is an incurable neurodegenerative disorder caused by a dominant mutation on the 4th chromosome. We aim to present a scientometric analysis of the extant scientific undertakings devoted to better understanding HD. Therefore, a quantitative study was performed to examine the current state-of-the-art approaches that foster researchers’ understandings of the current knowledge, research trends, and research gaps regarding this disorder. We performed literature searches of articles that were published up to September 2016 in the “ISI Web of Science™” (http://apps.webofknowledge.com/). The keyword used was “Huntington disease”. Of the initial 14,036 articles that were obtained, 7732 were eligible for inclusion in the study according to their relevance. Data were classified according to language, country of publication, year, and area of concentration. The country leader regarding the number of studies published on HD is the United States, accounting for nearly 30% of all publications, followed by England and Germany, who have published 10 and 7% of all publications, respectively. Regarding the language in which the articles were written, 98% of publications were in English. The first publication to be found on HD was published in 1974. A surge of publications on HD can be seen from 1996 onward. In relation to the various knowledge areas that emerged, most publications were in the fields of neuroscience and neurology, likely because HD is a neurodegenerative disorder. Publications written in areas such as psychiatry, genetics, and molecular biology also predominated.