Focus issue: conquering the data mountain.
Focus issue: conquering the data mountain.
复制标题
DOI：
10.1126/scisignal.2001871
复制
发表时间：
2011-02-15
影响因子：
7.3
通讯作者：
Yaffe, Michael B
中科院分区：
文献类型：
--
作者：
Gough, Nancy R;Yaffe, Michael B
高通量技术使细胞调控数据的获取迅速增加，如蛋白质-蛋白质相互作用、基因表达谱、蛋白质丰度变化的蛋白质组学分析和翻译后修饰的全局分析。现在社区面临的挑战是设计足够的标准来评估可靠性和注释、存储设施、共享机制以及可视化和分析工具。与《科学》杂志（http://www.sciencemag.org/special/data）合作，本期《科学信号》解决了一些与细胞信号研究人员面临的数据洪流相关的关键问题。
High-throughput technologies have enabled a rapid increase in the acquisition of data regarding cellular regulation, such as protein-protein interactions, gene expression profiling, proteomic analyses of changes in protein abundance, and global analyses of posttranslational modifications. The challenge now is for the community to devise adequate standards for assessing reliability and annotation, facilities for storage, mechanisms for sharing, and tools for visualization and analysis. In conjunction with Science (http://www.sciencemag.org/special/data), this issue of Science Signaling tackles some of the key issues related to the data deluge faced by cell signaling researchers.