Beat-to-beat and spectral analyses of the noninvasive radial pulse and laser-Doppler signals in patients with hypertension
Beat-to-beat and spectral analyses of the noninvasive radial pulse and laser-Doppler signals in patients with hypertension
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DOI：
10.3233/ch-201056
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发表时间：
2021-01-01
影响因子：
2.1
通讯作者：
Hsiu, Hsin
中科院分区：
文献类型：
--
作者：
Liu, Ju-Chi;Hsu, Yi-Ping;Hsiu, Hsin
本研究对20分钟皮肤表面激光多普勒血流仪（LDF）和径向血压波形（BPW）信号进行了搏动和频谱分析，以比较原发性高血压（EHT）患者和年龄匹配对照组的血流灌注状况和调节机制。逐拍LDF分析得出脉冲宽度（PW）、交直流比（AD）及其相应的变异性指数（变异系数[cv]）。计算了5个特征频率峰（定义为FR1-FR5）的相对能量贡献（rec）。频谱BPW分析得到各谐波分量n的幅值比例（C-n）和相位角（P-n）。EHT组FR2的PW、AD、AD_CV和REC显著小于对照组。在BPW指数方面，EHT患者的C-1、C-2、C-4和C-5显著高于对照组，P-2-P-8显著低于对照组。结果表明，BPW和LDF指标可用于评价EHT大鼠血流灌注效率和微循环调节活性。发现了性别差异，女性患者的影响更为明显。这些发现可能部分归因于内皮和神经调节功能的损害。目前的研究结果可能有助于开发新的非侵入性方法来降低eht引起的损伤的风险。
This study performed beat-to-beat and spectral analyses of 20-minute skin-surface laser-Doppler-flowmetry (LDF) and radial blood-pressure-waveform (BPW) signals in order to compare the blood-flow perfusion condition and regulatory mechanisms between essential-hypertension (EHT) patients and aged-matched control subjects. Beat-to-beat LDF analyses yielded the pulse width (PW), AC-to-DC ratio (AD), and their corresponding variability indices (coefficients of variation [CVs]). The relative energy contributions (RECs) of five characteristic frequency peaks (defined as FR1-FR5) were also calculated. Spectral BPW analysis obtained the amplitude proportion (C-n) and phase angle (P-n) of each harmonic component n. PW, AD, AD_CV, and REC of FR2 were significantly smaller in the EHT group than in the control group. Regarding BPW indices, C-1, C-2, C-4, and C-5 were significantly larger and P-2-P-8 were significantly smaller in EHT patients than in controls. The present results indicate that BPW and LDF indices can be used to evaluate the blood-flow perfusion efficiency and microcirculatory regulatory activities in EHT. Sex differences were found, with the effects being more prominent in female patients. These findings may be partly attributable to impairment of endothelial and neural regulatory functions. The present findings might aid the development of new noninvasive methods for reducing the risk of EHT-induced damage.