Adenosine deaminase activity and superoxide formation during phagocytosis and membrane perturbation of macrophages.
Adenosine deaminase activity and superoxide formation during phagocytosis and membrane perturbation of macrophages.
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巨噬细胞吞噬作用和膜扰动过程中的腺苷脱氨酶活性和超氧化物形成。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
P. Niswander
中科院分区：
文献类型：
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作者：
G. Tritsch;P. Niswander
在吞噬和膜扰动过程中，小鼠巨噬细胞产生的超氧化物与其胞内腺苷脱氨酶活性成正比。有人提出，由于腺苷脱氨酶控制黄嘌呤氧化酶可利用的底物数量，而后者在其底物的转换过程中产生超氧化物，嘌呤回收途径是巨噬细胞超氧化物需求的重要贡献者。进一步提出，这可能是腺苷脱氨酶缺乏与免疫缺陷相关机制的基础。
During phagocytosis and membrane perturbation, mouse macrophages generate superoxide in direct proportion to their intracellular adenosine deaminase activity. It is proposed that since adenosine deaminase controls the amount of substrate available to xanthine oxidase, and the latter produces superoxide during turnover of its substrates, the purine salvage pathway is an important contributor to the superoxide requirement of macrophages. It is further proposed that this may be the basis for the mechanism of the association of adenosine deaminase deficiency with immunodeficiency.