Factors Associated With Corneal Deformation Responses Measured With a Dynamic Scheimpflug Analyzer
Factors Associated With Corneal Deformation Responses Measured With a Dynamic Scheimpflug Analyzer
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DOI：
10.1167/iovs.16-21045
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发表时间：
2017-01-01
影响因子：
4.4
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
--
作者：
Miki, Atsuya;Maeda, Naoyuki;Nishida, Kohji
目的.本研究的目的是阐明动态Scheimpflug分析仪测量的角膜变形参数与基线因素如眼轴长度、眼内压（IOP）、年龄、中央角膜厚度（CCT）和角膜曲率之间的相关性。使用动态Scheimpflug分析仪检查了96名健康受试者（平均年龄55.2 ± 16.1岁）的96只眼睛。根据测量可靠性和临床相关性，选择35个变形参数中的18个进行分析。采用多元回归分析评估角膜变形参数与眼轴长度、IOP、年龄、CCT和平均角膜屈光力之间的关系。在多变量模型中，变形参数与眼轴长度（n = 13）、IOP（n = 13）、年龄（n = 8）和CCT（n = 6）显著相关。较长的眼轴长度对应于较大的角膜变形能力，较少的粘性阻尼，以及较少的运动的整个眼睛。高眼压与更大的角膜阻力和更少的运动的整个眼睛。年龄越大，角膜变形性越小，整个眼球的运动越大。角膜曲率仅与三个变形参数显著相关。本研究阐明了眼轴长度、年龄和IOP对角膜和整个眼睛的生物力学反应的实质性影响。相比之下，角膜曲率并不影响大多数的变形参数。目前的结果证实了角膜生物力学的重要性，特别是在眼轴较长的眼睛和老年受试者。
PURPOSE. The purpose of this study was to clarify correlations between corneal deformation parameters measured with a dynamic Scheimpflug analyzer and baseline factors such as axial length, intraocular pressure (IOP), age, central corneal thickness (CCT), and corneal curvature.METHODS. Ninety-six eyes of 96 healthy subjects (mean 55.2 +/- 16.1 years of age) were examined using a dynamic Scheimpflug analyzer. Eighteen of 35 deformation parameters were selected for analyses based on measurement reliability and clinical relevance. The associations between corneal deformation parameters and axial length, IOP, age, CCT, and average corneal power were evaluated using multivariate regression analyses.RESULTS. Deformation parameters were correlated significantly with axial length (n = 13), IOP (n = 13), age (n = 8), and CCT (n = 6) in the multivariate models. Longer axial length corresponded with greater corneal deformability, less viscous damping, and less movement of the entire eye. Higher IOP was associated with greater corneal resistance and less movement of the entire eye. Older age was associated with less corneal deformability and greater movement of the entire eye. Corneal curvature was correlated significantly with only three deformation parameters.CONCLUSIONS. This study clarified the substantial impact of axial length, age, and IOP on the biomechanical responses of the cornea and the entire eye. In contrast, corneal curvature did not affect most of the deformation parameters. The current results confirmed the importance of corneal biomechanics, especially in eyes with longer axial length and in older subjects.