Chiral Bronsted acid catalyzed enantioselective hydrophosphonylation of imines:: Asymmetric synthesis of α-amino phosphonates
Chiral Bronsted acid catalyzed enantioselective hydrophosphonylation of imines:: Asymmetric synthesis of α-amino phosphonates
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DOI：
10.1021/ol050695e
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发表时间：
2005-06-23
期刊：
影响因子：
5.2
通讯作者：
Fuchibe, K
中科院分区：
文献类型：
--
作者：
Akiyama, T;Morita, H;Fuchibe, K
衍生自 (R)-BINOL 的环状磷酸衍生物在室温下用亚磷酸二异丙酯对醛亚胺进行氢膦酰化时用作手性布朗斯台德酸 (10 mol%)。获得具有良好至高对映选择性的α-氨基膦酸酯。
A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Bronsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. alpha-Amino phosphonates were obtained with good to high enantioselectivities.