Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia:: A meta-analysis
Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia:: A meta-analysis
复制标题
DOI：
10.1086/345476
复制
发表时间：
2003-01-01
影响因子：
11.8
通讯作者：
Carmeli, Y
中科院分区：
文献类型：
--
作者：
Cosgrove, SE;Sakoulas, G;Carmeli, Y
进行荟萃分析，总结甲氧西林耐药对金黄色葡萄球菌菌血症死亡率的影响。检索MEDLINE数据库中1980年1月1日至2000年12月31日期间发表的研究，并进行文献综述，确定了S。金黄色菌血症如果研究包含耐甲氧西林链球菌患者的数量和死亡率，则纳入研究。金黄色葡萄球菌（MRSA）和甲氧西林敏感的S.金黄色葡萄球菌（MSSA）菌血症。提取患者的人口统计学特征、严重程度和共病校正、菌血症来源、住院死亡率的粗比值比（OR）和校正后的比值比（OR）及95%置信区间（CI）。当将结果与随机效应模型合并时，MRSA菌血症相关的死亡率明显增加（OR，1.93; 95%CI，1.54-2.42; P <0.001）;存在显著异质性。我们通过亚组分析探讨了异质性的原因。MRSA菌血症的死亡率明显高于MSSA菌血症。
A meta-analysis was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia. A search of the MEDLINE database for studies published during the period of 1 January 1980 through 31 December 2000 and a bibliographic review identified English-language studies of S. aureus bacteremia. Studies were included if they contained the numbers of and mortality rates for patients with methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) bacteremia. Data were extracted on demographic characteristics of the patients, adjustment for severity and comorbid illness, source of bacteremia, and crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for in-hospital mortality. When the results were pooled with a random-effects model, a significant increase in mortality associated with MRSA bacteremia was evident (OR, 1.93; 95% CI, 1.54-2.42; P < .001); significant heterogeneity was present. We explored the reasons for heterogeneity by means of subgroup analyses. MRSA bacteremia is associated with significantly higher mortality rate than is MSSA bacteremia.