[Anti-HIV drugs].
[Anti-HIV drugs].
复制标题
[抗HIV药物]。
DOI：
10.2222/jsv.63.199
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
T. Koibuchi
中科院分区：
文献类型：
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作者：
T. Koibuchi
抗HIV药物分为以下5类：核苷/核苷酸逆转录酶抑制剂（NRTI）、非核苷逆转录酶抑制剂（NNRTI）、蛋白酶抑制剂（PI）、整合酶链转移抑制剂（INSTI）和C-C趋化因子受体5型（CCR 5）抑制剂。抗艾滋病毒药物的适当组合，即ART（抗逆转录病毒疗法），可以长时间抑制艾滋病毒复制。由于最近开发了许多副作用相对较少且高效的抗HIV药物，因此无论患者的CD 4 + T细胞计数如何，都建议早期开始ART。然而，由于潜伏感染，ART并不能根除或治愈HIV。抗逆转录病毒疗法的中断导致病毒血症迅速反弹，需要终身治疗。因此，迫切需要从潜伏感染细胞中根除HIV的策略。
Anti-HIV drugs are fall into the following 5 categories: nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand transfer inhibitors (INSTIs), and C-C chemokine receptor type 5 (CCR5) inhibitors. An appropriate combination of anti-HIV drugs, which is called ART (anti-retroviral therapy), can suppress HIV replication for prolonged periods. Since many anti-HIV drugs with relatively few side effects as well as high-potency have been developed recently, early initiation of ART is recommended regardless of the patients' CD4+ T-cell counts. However, ART does not lead to eradication or cure of HIV because of latent infection. Interruption of ART leads to a rapid rebound of viremia, necessitating life-long treatment. Thus, strategies to eradicate HIV from latently infected cells are urgently needed.