TUMOR-ANGIOGRAPHY USING HIGH-RESOLUTION, 3-DIMENSIONAL MAGNETIC-RESONANCE-IMAGING - COMPARISON OF GADOPENTETATE DIMEGLUMINE AND A MACROMOLECULAR BLOOD-POOL CONTRAST AGENT
TUMOR-ANGIOGRAPHY USING HIGH-RESOLUTION, 3-DIMENSIONAL MAGNETIC-RESONANCE-IMAGING - COMPARISON OF GADOPENTETATE DIMEGLUMINE AND A MACROMOLECULAR BLOOD-POOL CONTRAST AGENT
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DOI：
10.1016/s1076-6332(05)80059-5
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发表时间：
1995-10-01
影响因子：
4.8
通讯作者：
BRASCH, RC
中科院分区：
文献类型：
--
作者：
SCHWICKERT, HC;STISKAL, M;BRASCH, RC
理由和目标。我们使用顺磁性细胞外或大分子造影剂结合高分辨率磁共振（MR）成像比较了大鼠肿瘤周围血管的定义。在给药钆喷酸葡胺（0.1 mmol Gd/kg; n = 10）和白蛋白-（Gd-DTPA）（30）（0.05 mmol Gd/kg; n = 5）之前、之后即刻和之后40 min，从荷瘤Fischer-344大鼠中采集高分辨率三维破坏梯度重聚焦稳态采集（SPGR）图像。使用4分评分系统在最大强度投影血管造影片上对瘤周小血管进行半定量分析;定量分析包括信噪比（SBRs）和信噪比。结果。钆喷酸葡胺引起短暂和低评分（0.2 +/- 0.1，SBR = 1.9 +/- 0.2）血管清晰，但边缘增强较强（评分= 1.4 +/- 0.2）。白蛋白-（Gd-DTPA）（30）产生了持续的高质量血管造影（评分= 2.6 +/- 0.2，SBR = 7.4 +/- 0.2），但边缘增强最小（评分= 0.3 +/- 0.2）。白蛋白-（Gd-DTPA）（30）结合高分辨率MR成像可对瘤周血管进行时间持久性、详细的血管造影定义。用钆喷酸葡胺增强获得的血管图不是时间持续性的或质量相同的。
Rationale and Objectives. We compared the peritumoral vascular definition in rats using either a paramagnetic extracellular or a macromolecular contrast medium in combination with high-resolution magnetic resonance (MR) imaging.Methods. High-resolution, three-dimensional spoiled gradient-refocused acquisition in a steady state (SPGR) images were acquired from tumor-bearing Fischer-344 rats before, immediately after, and again 40 min after administration of gadopentetate dimeglumine (0.1 mmol Gd/kg; n = 10) and albumin-(Gd-DTPA)(30) (0.05 mmol Gd/kg; n = 5). Small peritumoral vessels were analyzed semiquantitatively on maximum intensity projection angiograms using a 4-point scoring system; quantitative analyses included signal-to-background ratios (SBRs) and signal-to-noise ratios.Results. Gadopentetate dimeglumine caused a transient and low-scoring (0.2 +/- 0.1, SBR = 1.9 +/- 0.2) vessel definition but strong rim enhancement (score = 1.4 +/- 0.2). Albumin-(Gd-DTPA)(30) produced persistent, high-quality angiograms (score = 2.6 +/- 0.2, SBR = 7.4 +/- 0.2) but minimal rim enhancement (score = 0.3 +/- 0.2).Conclusion. Albumin-(Gd-DTPA)(30) combined with high-resolution MR imaging produces time-persistent, detailed angiographic definition of peritumoral vessels. Vascular maps obtained with gadopentetate dimeglumine enhancement are not time persistent or of equal quality.