Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles
Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles
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DOI：
10.2337/diab.46.11.1667
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发表时间：
1997-11
期刊：
影响因子：
7.7
通讯作者：
S. Rea;D. James
中科院分区：
文献类型：
--
作者：
S. Rea;D. James
肌肉和脂肪细胞中的GLUT4系统在全身葡萄糖稳态中起着重要作用。胰岛素刺激GLUT4从细胞内储存室转移到细胞表面。这个隔间的性质在很大程度上仍不清楚。我们综述了最近描述GLUT4储存室的生物发生和分子组成的研究，并得出结论：GLUT4是从内体和生物合成途径中分离出来的。此外，我们提出的证据表明，GLUT4储存室直接移动到质膜对胰岛素的反应，因此，类似于神经元中的小突触小泡。我们建议将GLUT4储存室称为GLUT4储存囊或GSV。
The GLUT4 system in muscle and fat cells plays an important role in whole-body glucose homeostasis. Insulin stimulates the translocation of GLUT4 from an intracellular storage compartment to the cell surface. The nature of this compartment remains largely unknown. We review recent studies describing the biogenesis and molecular constituents of the GLUT4 storage compartment and conclude that it is segregated from the endosomal and biosynthetic pathways. Further, we present evidence to suggest that the GLUT4 storage compartment moves directly to the plasma membrane in response to insulin and, hence, is analogous to small synaptic vesicles in neurons. We propose that the GLUT4 storage compartment be referred to as GLUT4 storage vesicles or GSVs.