Solid phase organic synthesis and combinatorial chemistry: A laboratory preparation of oligopeptides
Solid phase organic synthesis and combinatorial chemistry: A laboratory preparation of oligopeptides
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固相有机合成和组合化学：寡肽的实验室制备
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
J. Markgraf
中科院分区：
文献类型：
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作者：
G. Truran;Karelle S. Aiken;Thomas Fleming;Peter J. Webb;J. Markgraf
利用固相有机合成和组合化学的原理和实践在实验室制备寡肽。平行合成方案用于产生一系列三肽。发散合成方案用于制备两种五肽，其中一种是亮氨酸脑啡肽，一种已知为镇痛剂的神经递质。
The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.