Induction of immune responses and partial protection in mice after skin immunization with rotavirus VP6 protein and the adjuvant LT(R192G).
Induction of immune responses and partial protection in mice after skin immunization with rotavirus VP6 protein and the adjuvant LT(R192G).
复制标题
轮状病毒VP6蛋白和佐剂LT(R192G)皮肤免疫小鼠后诱导免疫反应和部分保护。
DOI：
10.1016/j.vaccine.2005.01.028
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发表时间：
2005
期刊：
影响因子：
5.5
通讯作者：
Basu,Mitali
中科院分区：
文献类型：
--
作者：
Choi,AnthonyH-C;Smiley,Kristi;Basu,Mitali
Oral or intranasal administration of mice with rotavirus VP6/LT(R192G) vaccine induces between 95 and 99% protection against fecal shedding of rotavirus after challenge. However, mucosal administration of LT(R192G) is controversial. Subcutaneous, intradermal or Biojector injection induced high titers of serum VP6-specific IgG, eliciting only partial to no protection (73, 0 and 26%, respectively), while transcutaneous delivery using gauze pad induced both poor immune responses and no protection (13%). A mixture of VP6-derived synthetic peptides induced >97, 48 and 33% protection after intranasal, gauze pad or Biojector administration, respectively. For needle-free delivery methods to be viable, improvements to these methods must be made to enhance the efficacy of the VP6 vaccine.
