STREPTOCOCCUS-MUTANS-INDUCED NEPHRITIS IN RABBITS - RHEUMATOID FACTORS AND NEPHRITOGENICITY
STREPTOCOCCUS-MUTANS-INDUCED NEPHRITIS IN RABBITS - RHEUMATOID FACTORS AND NEPHRITOGENICITY
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DOI：
10.1159/000237183
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发表时间：
1995-12-01
影响因子：
2.8
通讯作者：
ALBINI, B
中科院分区：
文献类型：
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作者：
MIYATA, M;GLURICH, I;ALBINI, B
链球菌性肾炎（SIN）的发病机制涉及免疫复合物介导的炎症，然而，具体机制仍然知之甚少。使用两种变形链球菌（SM）菌株的制剂试图诱导家兔SIN，一种制剂强烈，另一种几乎不致肾炎。非致肾炎制剂为我们的研究提供了阴性对照。链球菌成分存在于循环免疫复合物（CIC）以及组织结合免疫复合物（TIG）中，特别是在疾病早期。CIC和TIC还含有类风湿因子（RF），在疾病的晚期往往占主导地位。SM的致肾炎和非致肾炎制剂具有相同的主要组织结合成分，并诱导相似的抗微生物抗体滴度，但其诱导CIC和RE的能力显着不同。建议肾结合微生物成分，抗微生物抗体和高血清RF浓度是SIN在此兔模型中发病的必要和充分的决定因素。
The pathogenesis of streptococcus-induced nephritides (SIN) involves immune complex-mediated inflammation; however, specific mechanisms are still poorly understood. Using preparations of two strains of Streptococcus mutans (SM) in attempts to induce SIN in rabbits, one preparation was strongly and the other virtually not nephritogenic. The non-nephritogenic preparation provided a negative control for our studies. Streptococcal components were present in circulating immune complexes (CIC) as well as in tissue-bound immune complexes (TIG), especially early in the disease. CIC and TIC also contained rheumatoid factors (RF), which tended to predominate in late stages of the disease. The nephritogenic and the non-nephritogenic preparations of SM shared the same major tissue-binding components and induced similar titers of antimicrobial antibodies, but differed significantly in their ability to induce CIC and RE It is proposed that kidney-binding microbial components, antimicrobial antibodies and high serum concentration of RF are necessary and sufficient determinants for the pathogenesis of SIN in this rabbit model.