Controllable Assembly of MoVI36-Based Polyoxometalate Porous Frameworks with Silver Ions and Lung Cancer Cell-Specific Cytotoxicity
Controllable Assembly of MoVI36-Based Polyoxometalate Porous Frameworks with Silver Ions and Lung Cancer Cell-Specific Cytotoxicity
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DOI：
10.1021/acs.chemmater.1c03837
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发表时间：
2022-03
影响因子：
8.6
通讯作者：
Hui-Min Zeng;Boxing Jin;Wei-Hong Wu;Chao Wang;Zhan-Guo Jiang;Zhigang Jin;Cai‐Hong Zhan
中科院分区：
文献类型：
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作者：
Hui-Min Zeng;Boxing Jin;Wei-Hong Wu;Chao Wang;Zhan-Guo Jiang;Zhigang Jin;Cai‐Hong Zhan
具有明确二级结构单元（SBU）的纯无机聚氧乙烯（POM）沸石材料的可控结构是一个巨大的挑战。在本工作中，三种不同的基于[MoVI 36 O 112（H2O）16]8-（{Mo 36}）SBU的POM多孔骨架化合物1 - 3具有不同的活性生长点和过渡金属Ag连接体，两者都作为抗衡阳离子和结构导向剂，从简单盐自组装成有序的多孔骨架（化合物1是具有直径为20.1 μ m的通道的3D框架，而化合物2和化合物3分别是具有直径为29.1 μ m和26.8 μ m的通道的2D框架，通过控制反应条件，使{Mo_（36）SBU）四重螺旋缠绕形成化合物3的孔道，为合成化学家获得更多有趣的功能材料提供了宝贵的经验。基于{Mo 36}的POM多孔框架化合物1 - 3表现出细胞类型特异性、剂量依赖性和pH敏感性的抗癌行为，在A549肺癌细胞中IC 50最低。此外，单体前体AgNO 3和Mo 36 SBU对A549细胞的细胞毒性低于化合物Ag-{Mo 36}，表明杂化材料的协同作用。对化合物1 - 3的抗癌活性的机理的了解表明，它们诱导A549细胞中的细胞凋亡和坏死。因此，含银离子的{Mo 36}基POM多孔骨架材料可作为肺癌治疗的有希望的抗癌剂。
The controllable construction of pure inorganic polyoxometalate (POM)zite materials with well-defined secondary building units (SBUs) is of great challenge. In this work, three distinct POM porous framework compounds1–3based on [MoVI36O112(H2O)16]8–({Mo36}) SBUs with various active growth points and transition-metal Ag linkers, both as countercations and structure directors, were self-assembled from simple salts to ordered porous frameworks (compound1is a 3D framework with channels of 20.1 Å in diameter, while compound2and compound3are 2D frameworks with channels of 29.1 and 26.8 Å in diameter, respectively, and the channels of compound3are formed by the fourfold spiral winding of {Mo36} SBUs) by controlling the reaction conditions, providing valuable experience for synthetic chemists to obtain more interesting and functional materials. The {Mo36}-based POM porous framework compounds1–3exhibit cell type-specific, dose-dependent, and pH-sensitive anticancer behavior, with the lowest IC50in A549 lung cancer cells. Further, the monomer precursors AgNO3and Mo36SBU, however, are less cytotoxic to A549 cells than compound Ag–{Mo36}, suggesting a synergistic action of hybrid materials. Mechanistic insights into the anticancer activity of compounds1–3show that they induce mitochondria-mediated apoptosis and necrosis in A549 cells. Thus, {Mo36}-based POM porous framework materials with silver ions could serve as promising anticancer agents for lung cancer therapy.