Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
复制标题
DOI：
10.1182/blood.v94.6.1840
复制
发表时间：
1999-09-15
期刊：
影响因子：
20.3
通讯作者：
Chiorazzi, N
中科院分区：
文献类型：
--
作者：
Damle, RN;Wasil, T;Chiorazzi, N
对一组随机选择的IgM（+）B-慢性淋巴细胞白血病（B-CLL）病例进行细胞免疫表型研究，其中IG V-H和V-L基因序列可用。根据V基因突变状态和CD 38表达对病例进行分类，并分析治疗史和生存期。B-CLL可分为两组。与具有较低CD 38（+）细胞百分比的突变V基因的患者相比，具有未突变V基因的患者显示出较高的CD 38（+）B-CLL细胞百分比（大于或等于30%）。
Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM(+) B-chronic lymphocytic leukemia (B-CLL) cases for which Ig V-H and V-L gene sequences were available. The cases were categorized based on V gene mutation status and CD38 expression and analyzed for treatment history and survival. The B-CLL cases could be divided into 2 groups. Those patients with unmutated V genes displayed higher percentages of CD38(+) B-CLL cells (greater than or equal to 30%) than those with mutated V genes that had lower percentages of CD38(+) cells (