Invited Commentary: Women's Reproductive Life Spans and Subsequent Inflammatory Profiles-How to Best Measure Reproductive Life Span and the Need for Baseline Assessments.
Invited Commentary: Women's Reproductive Life Spans and Subsequent Inflammatory Profiles-How to Best Measure Reproductive Life Span and the Need for Baseline Assessments.
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特邀评论：女性的生殖寿命和随后的炎症特征——如何最好地测量生殖寿命和基线评估的需要。
DOI：
10.1093/aje/kwz266
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发表时间：
2020
影响因子：
5
通讯作者：
Schliep,KarenC
中科院分区：
文献类型：
--
作者：
Schliep,KarenC
众所周知，炎症过程会导致多种慢性疾病的发病机制，包括心血管疾病和阿尔茨海默病以及全因死亡率。新兴研究表明，生育寿命较长的女性（大致确定为从初潮到绝经的时期或考虑无排卵时间跨度后的终生排卵周期数）患这些与炎症相关的慢性疾病的风险较低。矛盾的是，已知排卵会诱发急性炎症。鉴于评估生殖寿命与后期炎症特征之间关系的研究有限，Huang 等人。 (Am J Epidemiol.2020;189(7):660–670) 着手在两项最有力的女性纵向队列研究（护士健康研究）中调查这种关系。他们发现，在调整其他炎症相关因素（包括肥胖、运动和饮食）后，绝经前和绝经后女性的终生排卵年数与较低的 C 反应蛋白水平相关。黄等人。提请注意女性生殖寿命研究中的几个挑战，包括如何正确捕获终生排卵周期，以及如果我们希望了解将生殖因素与随后的慢性疾病联系起来的致病过程，则需要在整个生命过程中重复测量炎症生物标志物。
Inflammatory processes are known to drive the pathogenesis of several chronic diseases, including cardiovascular disease and Alzheimer disease, as well as all-cause mortality. Emerging research indicates that women who have a longer reproductive life span—roughly determined as the period from menarche to menopause or lifetime number of ovulatory cycles after accounting for anovulatory time spans—are at lower risk for these inflammation-related chronic diseases. The paradox is that ovulation is known to induce acute inflammation. Given the limited research assessing the relationship between reproductive life span and later inflammatory profiles, Huang et al. (Am J Epidemiol.2020;189(7):660–670) set out to investigate this relationship within 2 of the most robust longitudinal cohort studies of women, the Nurses’ Health studies. They found that after adjustment for other inflammation-related factors, including adiposity, exercise, and diet, lifetime ovulatory years was associated with lower C-reactive protein levels in both premenopausal and postmenopausal women. Huang et al. call attention to several challenges in research on women’s reproductive life spans, including how to appropriately capture lifetime ovulatory cycles and the need for repeated measurements of inflammatory biomarkers across the life course if we wish to understand pathogenic processes linking reproductive factors to subsequent chronic disease.