New Compounds from the Roots and Stems of Trigonostemon lii and Their Cytotoxic Activities.
New Compounds from the Roots and Stems of Trigonostemon lii and Their Cytotoxic Activities.
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DOI：
10.1002/chin.201649183
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发表时间：
2016-11
期刊：
影响因子：
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通讯作者：
Yong-Qin Liu;Y. Di;Yue-Hu Wang;X. Hao;Xu-Jia Hu
中科院分区：
文献类型：
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作者：
Yong-Qin Liu;Y. Di;Yue-Hu Wang;X. Hao;Xu-Jia Hu
从胡芦巴（Trigonostemonlii）的根和茎中分离得到一个新的咔啉生物碱Trifiline D（1）和一个新的降解二萜化合物Trigoxyphin X（4）。通过广泛的光谱分析（包括1D-和2D-NMR技术）阐明了它们的结构。化合物1对MCF-7、A-549、MGC-803和科洛-205表现出弱抑制活性，IC 50值范围为27.4 - 35.4 μm。
A new carboline alkaloid, Trifiline D (1) and a new degraded diterpenoid, Trigoxyphin X (4) were isolated from the roots and stems ofTrigonostemonlii. Their structures were elucidated by extensive spectroscopic analyses including 1D‐ and 2D‐NMR techniques. Compound1exhibited weak inhibitory activity against MCF‐7, A‐549, MGC‐803, and COLO‐205 withIC50values ranging from 27.4 to 35.4 μm.