Longitudinal effects of noninvasive positive-pressure ventilation in patients with amyotrophic lateral sclerosis
Longitudinal effects of noninvasive positive-pressure ventilation in patients with amyotrophic lateral sclerosis
复制标题
DOI：
10.1097/01.phm.0000078239.83545.d0
复制
发表时间：
2003-08-01
影响因子：
3
通讯作者：
Schreiber, H
中科院分区：
文献类型：
--
作者：
Butz, M;Wollinsky, KH;Schreiber, H
目标：评估肌萎缩侧索硬化症患者使用无创正压通气对症状、生活质量和生存率的持续获益。设计：在这项前瞻性队列研究中，36名连续转诊的有症状患者中，有30名患者耐受夜间无创正压通气，并接受了肺功能测试以及12项有关睡眠质量的症状和生活质量仪器，白天嗜睡，身体疲劳，精神疲劳，抑郁症，在10个月的periods.Results管理：与治疗，有一个显着的改善，在大多数患者的睡眠质量，白天嗜睡，身体疲劳，抑郁症，然而，显着的改善持续长达10个月，只有在睡眠质量。在使用部分时间无创正压通气期间，动脉血氧分压、动脉二氧化碳分压和血氧饱和度保持稳定甚至改善长达7个月。共有14例患者的生存期延长持续依赖于无创正压ventilation.Conclusions：无创正压通气提供了一个长期的好处肌萎缩侧索硬化症患者的症状和生活质量指标，并应提供给所有患者的睡眠呼吸障碍或吸气肌功能障碍的症状。它还可以延长无气管造口术的生存期。
Objective: To evaluate the duration of benefit on symptoms, quality of life, and survival derived from the use of noninvasive positive-pressure ventilation by patients with amyotrophic lateral sclerosis.Design: In this prospective, cohort study, 30 of 36 consecutively referred symptomatic patients tolerated nightly noninvasive positive-pressure ventilation and undertook pulmonary function testing and 12 symptom and quality-of-life instruments concerning sleep quality, daytime sleepiness, physical fatigue, mental fatigue, and depression that were administered during a 10-mo period.Results: With treatment, there was a significant improvement in the majority of patients in sleep quality, daytime sleepiness, physical fatigue, and depression; however, significant improvements lasted for up to 10 mo only in sleep quality. Partial pressure of arterial oxygen, partial pressure of arterial carbon dioxide, and oxyhemoglobin saturation remained stable or even improved for up to 7 mo during use of part-time noninvasive positive-pressure ventilation. A total of 14 patients had survival prolonged by continuous dependence on noninvasive positive-pressure ventilation.Conclusions: Noninvasive positive-pressure ventilation provides a long-lasting benefit on symptoms and quality of life indicators for amyotrophic lateral sclerosis patients and should be offered to all patients with symptoms of sleep disordered breathing or inspiratory muscle dysfunction. It can also prolong tracheostomy-free survival.