Neuronal distribution in the neocortex of schizophrenic patients
Neuronal distribution in the neocortex of schizophrenic patients
复制标题
DOI：
10.1016/j.psychres.2006.12.009
复制
发表时间：
2008-04-15
影响因子：
11.3
通讯作者：
Schmitz, Christoph
中科院分区：
文献类型：
--
作者：
Casanova, Manuel F.;Kreczmanski, Pawel;Schmitz, Christoph
It has been Postulated that the prefrontal cortices of schizophrenic patients have significant alterations in their neuropil space. However, previous results have been contradictory and inconclusive, reporting both decreases and increases in the prefrontal neuropil. The present study re-examines these findings based on measurements of cell density, and inter-cellular distances within and between cell minicolumns. The results indicate alterations in the neuropil of schizophrenic patients according to both the lamina and cortical area examined. Alterations were present in all cortical areas studied. The findings Suggest an alteration in the modulatory systems innervating the cell minicolumn. Furthermore, the lack of variation in core columnarity parameters argues in favor of a defect post-dating the formation of the cell minicoloumn. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
