L-Type Calcium Channels: On the Fast Track to Nuclear Signaling
L-Type Calcium Channels: On the Fast Track to Nuclear Signaling
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DOI：
10.1126/scisignal.2003355
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发表时间：
2012-08-14
影响因子：
7.3
通讯作者：
Dolphin, Annette C.
中科院分区：
文献类型：
--
作者：
D'Arco, Marianna;Dolphin, Annette C.
神经元去极化产生的钙信号传导可以触发转录变化，这种反应被称为兴奋转录（E-T）耦合。在神经元中，电压门控和配体门控的钙渗透通道有助于细胞内钙的增加。看来，由特定电压门控钙通道介导的钙信号可能在 E-T 耦合中具有不同的作用。
Calcium signaling resulting from depolarization of neurons can trigger changes in transcription, and this response has been called excitation-transcription (E-T) coupling. In neurons, voltage-gated and ligand-gated calcium-permeable channels contribute to the increase in intracellular calcium. It appears that calcium signals mediated by specific voltage-gated calcium channels may have distinct roles in E-T coupling.