Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update.
Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update.
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DOI：
10.1155/2016/6146595
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Rasool M
中科院分区：
文献类型：
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作者：
Malik A;Sultana M;Qazi A;Qazi MH;Parveen G;Waquar S;Ashraf AB;Rasool M
癌症起源于基因突变的积累。肿瘤干细胞被描述为能够分化和自我更新的致瘤细胞。癌症干细胞被认为对常规治疗如化疗和放疗有抵抗力。放射治疗和化学治疗损害癌DNA细胞。由于癌症干细胞具有自我更新和繁殖恶性肿瘤的能力，因此它们是深入研究的主题。本文从DNA损伤反应和天然放射增敏剂两个方面综述了CSCs的辐射抗性机制。活性氧在不同的生理过程中起着重要的作用。ROS清除负责调节活性氧的产生。研究人员已经证明microRNA调节肿瘤的辐射抗性。电离辐射不会杀死癌细胞;相反，IR只是减缓了症状和体征。电离辐射直接或间接损伤DNA。IR主要与其他化疗/放疗联合使用。我们在这里简要描述了癌症干细胞的行为和癌症治疗中的放射抗性疗法。为了克服癌症治疗中的放射抗性，已经实践了诸如分级修饰、组合治疗、炎症修饰和克服缺氧肿瘤的策略。天然放射增敏剂，例如姜黄素、染料木素和槲皮素，比合成化合物更有益。
Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomic DNA cells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is given mostly in combination with other chemo/radiotherapies. We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds.