Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals.
Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals.
复制标题
在哺乳动物夜间视觉演变过程中，从短波长敏感锥中募集杆感光体。
DOI：
10.1016/j.devcel.2016.05.023
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发表时间：
2016-06-20
影响因子：
11.8
通讯作者：
Swaroop A
中科院分区：
文献类型：
--
作者：
Kim JW;Yang HJ;Oel AP;Brooks MJ;Jia L;Plachetzki DC;Li W;Allison WT;Swaroop A
脊椎动物的祖先只有锥状感光器。随着高度感光的杆状光感受器的出现，双重视网膜在无颌脊椎动物中进化而来。尽管视锥细胞是高分辨率彩色视觉的仲裁者，但在哺乳动物进化的早期，视杆细胞在夜间阶段成为主要的感光细胞。我们调查了两个不同的脊椎动物视网膜杆的进化和发育起源。在小鼠中，我们发现了遗传和表观遗传痕迹的短波长锥在发展中的杆和细胞谱系跟踪验证了杆的起源从S-锥。令人好奇的是，斑马鱼的视杆细胞并不是从S-视锥细胞衍生而来的。我们的研究阐明了关于双重视网膜进化的几个问题，并支持这一假设，即在哺乳动物中，S-锥谱系是通过Maf家族转录因子NRL招募的，以增加视杆细胞。我们建议，这种发展机制允许适应性开发的暗视壁龛在夜间瓶颈哺乳动物进化的早期。杆状视网膜的进化是一种关键的适应，使哺乳动物的祖先能够在夜间瓶颈中生存下来。Kim等人提供的证据表明，这种进化转变是由Maf家族蛋白NRL的分子创新驱动的，这导致了早期哺乳动物从S-视锥细胞中招募视杆细胞。
Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite cones being the arbiters of high-resolution color vision, rods emerged as the dominant photoreceptor in mammals during a nocturnal phase early in their evolution. We investigated the evolutionary and developmental origins of rods in two divergent vertebrate retinae. In mice, we discovered genetic and epigenetic vestiges of short wavelength cones in developing rods and cell lineage tracing validated the genesis of rods from S-cones. Curiously, rods did not derive from S-cones in zebrafish. Our study illuminates several questions regarding the evolution of duplex retina and supports the hypothesis that, in mammals, the S-cone lineage was recruited via the Maf-family transcription factor NRL to augment rod photoreceptors. We propose that this developmental mechanism allowed the adaptive exploitation of scotopic niches during the nocturnal bottleneck early in mammalian evolution. The evolution of rod-dominant retinae was a critical adaptation, allowing mammalian ancestors to survive a nocturnal bottleneck. Kim et al. provide evidence suggesting that this evolutionary transition was driven by molecular innovations in the Maf-family protein NRL, which led to the recruitment of rods from S-cones in early mammals.