ACQUIRED IMMUNE TOLERANCE TO CADAVERIC RENAL-ALLOGRAFTS - A STUDY OF 3 PATIENTS TREATED WITH TOTAL LYMPHOID IRRADIATION
ACQUIRED IMMUNE TOLERANCE TO CADAVERIC RENAL-ALLOGRAFTS - A STUDY OF 3 PATIENTS TREATED WITH TOTAL LYMPHOID IRRADIATION
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DOI：
10.1056/nejm198907063210106
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发表时间：
1989-07-06
影响因子：
158.5
通讯作者：
LEVIN, B
中科院分区：
文献类型：
--
作者：
STROBER, S;DHILLON, M;LEVIN, B
在这十年中，新的免疫抑制药物方案的出现大大提高了同种异体器官移植的存活率。12345然而，器官移植受者的治疗仍然涉及终身使用免疫抑制药物，如环孢素和类固醇，以维持移植物功能。12345与长期使用环孢素相关的副作用包括肾毒性、肝毒性、神经毒性、高血压、多毛症、牙龈肥大和淋巴样癌。6,7长期类固醇治疗的累积毒性可导致高血压、糖尿病、骨质疏松、骨无菌性坏死、感染、液体潴留和毛细血管易碎性增加。8,9器官移植的一个持续目标是通过停止维持来消除这些副作用。
The advent of new immunosuppressive drug regimens has produced a substantial improvement in organ-allograft survival during this decade.12345However, the treatment of organ-transplant recipients still involves the lifelong use of immunosuppressive drugs such as cyclosporine and steroids to maintain graft function.12345Side effects associated with the long-term use of cyclosporine include nephrotoxicity, hepatotoxicity, neurotoxicity, hypertension, hypertrichosis, gingival hypertrophy, and lymphoid cancers.6,7The cumulative toxicity of long-term steroid therapy can lead to hypertension, diabetes, osteoporosis, aseptic necrosis of bone, infection, fluid retention, and increased capillary fragility.8,9A continued goal in organ transplantation is to eliminate these side effects by withdrawing maintenance . . .